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[Nucleic Acids Res. 2020] NPInter v4.0: an integrated database...

发表日期:2021-05-17 11:04:56

 2020 Jan 8;48(D1):D160-D165. doi: 10.1093/nar/gkz969.

NPInter v4.0: an integrated database of ncRNA interactions.

Xueyi Teng1 2 Xiaomin Chen1 2Hua Xue1 2Yiheng Tang1 2Peng Zhang1Quan Kang1Yajing Hao1 2Runsheng Chen1 2 3Yi Zhao4Shunmin He1 2 .

Abstract

Noncoding RNAs (ncRNAs) play crucial regulatory roles in a variety of biological circuits. To document regulatory interactions between ncRNAs and biomolecules, we previously created the NPInter database (http://bigdata.ibp.ac.cn/npinter). Since the last version of NPInter was issued, a rapidly growing number of studies have reported novel interactions and accumulated numerous high-throughput interactome data. We have therefore updated NPInter to its fourth edition in which are integrated 600 000 new experimentally identified ncRNA interactions. ncRNA-DNA interactions derived from ChIRP-seq data and circular RNA interactions have been included in the database. Additionally, disease associations were annotated to the interacting molecules. The database website has also been redesigned with a more user-friendly interface and several additional functional modules. Overall, NPInter v4.0 now provides more comprehensive data and services for researchers working on ncRNAs and their interactions with other biomolecules.


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